abstract：BACKGROUND:Anticoagulation using vitamin K antagonists (VKAs) significantly reduces the risk of recurrent stroke in stroke patients with atrial fibrillation (AF) and is recommended by guidelines. METHODS:The German Competence NETwork on Atrial Fibrillation established a nationwide prospective registry including 9,574 ...

journal_title：BMC neurology

authors： Haeusler KG,Gerth A,Limbourg T,Tebbe U,Oeff M,Wegscheider K,Treszl A,Ravens U,Meinertz T,Kirchhof P,Breithardt G,Steinbeck G,Nabauer M,AFNET registry investigators.

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:The reliable and efficient measurement of spinal cord atrophy is of growing interest in monitoring disease progression in multiple sclerosis (MS). METHODS:We compared T1- and T2-weighted MRI for measuring cervical spinal cord volume in 31 patients with MS and 18 age-matched controls (NC) from T1-weighted gr...

journal_title：BMC neurology

authors： Kim G,Khalid F,Oommen VV,Tauhid S,Chu R,Horsfield MA,Healy BC,Bakshi R

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is associated with vascular risk factors; brain ischemia facilitates the pathogenesis of AD. Recent studies have suggested that the reduction of AD risk with statin was achieved by decreased amyloidogenic amyloid precursor protein. METHODS:We used mitochondrial transgenic neuronal c...

journal_title：BMC neurology

authors： Jeong JH,Yum KS,Chang JY,Kim M,Ahn JY,Kim S,Lapchak PA,Han MK

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:A Transient Ischaemic Attack (TIA) bears a high risk of a subsequent ischaemic stroke. Adequate diagnosis of a TIA should be followed immediately by the start of appropriate preventive therapy, including antiplatelets. The diagnosis of a TIA based on symptoms and signs only is notoriously difficult and bioma...

journal_title：BMC neurology

authors： Dolmans LS,Rutten FH,El Bartelink ML,Seppenwoolde G,van Delft S,Kappelle LJ,Hoes AW

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is an autosomal recessive inherited disease of metabolic dysfunction clinically characterized by fluctuating proximal muscle weakness, excise intolerance, and dramatic riboflavin responsiveness. Dropped head syndrome can occasionally be observed in...

journal_title：BMC neurology

authors： Peng Y,Zhu M,Zheng J,Zhu Y,Li X,Wei C,Hong D

更新日期：2015-07-24 00:00:00

abstract：BACKGROUND:The evidence base for the effectiveness of psychological interventions for patients with dissociative non-epileptic seizures (DS) is currently extremely limited, although data from two small pilot randomised controlled trials (RCTs), including from our group, suggest that Cognitive Behavioural Therapy (CBT) ...

journal_title：BMC neurology

authors： Goldstein LH,Mellers JD,Landau S,Stone J,Carson A,Medford N,Reuber M,Richardson M,McCrone P,Murray J,Chalder T

更新日期：2015-06-27 00:00:00

abstract：BACKGROUND:Due to lack of any curative therapy for ALS, symptomatic treatment and maintenance of quality of life (QoL) is very important. We aimed to characterize the affected domains of QoL in ALS patients and to identify factors which are associated with reduced QoL and increased depression. METHODS:159 ALS patients...

journal_title：BMC neurology

authors： Körner S,Kollewe K,Abdulla S,Zapf A,Dengler R,Petri S

更新日期：2015-05-16 00:00:00

abstract：BACKGROUND:Different studies have found diminished cardiac metaiodobenzylguanidine (MIBG) uptake in Lewy body (LB) related conditions (Parkinson's disease (PD) and Lewy body dementia (LBD)). However, delayed heart/mediastinum (d-H/M) ratio diagnostic cutoff points are debated in parkinsonian syndromes. METHODS:We perf...

journal_title：BMC neurology

authors： Lamotte G,Morello R,Lebasnier A,Agostini D,Defer GL

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid (Aβ) peptides in the wall of brain vasculature, commonly involving capillaries and arterioles. Also being considered a part of CAA is the Aβ deposition in leptomeninge. The cellular origin of angiopathic Aβ and the pathogenic course of C...

journal_title：BMC neurology

authors： Xue ZQ,He ZW,Yu JJ,Cai Y,Qiu WY,Pan A,Gai WP,Cai H,Luo XG,Ma C,Yan XX

更新日期：2015-05-02 00:00:00

abstract：BACKGROUND:Decision-making is an essential function of everyday life. Decision-making under explicit risk requires developing advantageous decision strategies based on fixed outcomes (e.g., probabilities of winning or losing a bet). Decision-making and its neural substrates have been rarely studied in MS. We expected p...

journal_title：BMC neurology

authors： Radomski AD,Power C,Purdon SE,Emery DJ,Blevins G,Warren KG,Fujiwara E

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear. METHODS:Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9; 32% aged 60+; median ...

journal_title：BMC neurology

authors： Cysique LA,Hewitt T,Croitoru-Lamoury J,Taddei K,Martins RN,Chew CS,Davies NN,Price P,Brew BJ

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Cognitive impairment commonly occurs in the acute phase post-stroke, but may persist with over half of all stroke survivors experiencing some form of long-term cognitive deficit. Recent evidence suggests that optimising secondary prevention adherence is a critical factor in preventing recurrent stroke and th...

journal_title：BMC neurology

authors： Mellon L,Brewer L,Hall P,Horgan F,Williams D,Hickey A,ASPIRE-S study group.

更新日期：2015-03-12 00:00:00

abstract：BACKGROUND:The prognostic impact of preadmission use of calcium channel blockers (CCBs) and beta blockers (BBs) on stroke mortality remains unclear. We aimed to examine whether preadmission use of CCBs or BBs was associated with improved short-term mortality following ischemic stroke, intracerebral hemorrhage (ICH), or...

journal_title：BMC neurology

authors： Sundbøll J,Schmidt M,Horváth-Puhó E,Christiansen CF,Pedersen L,Bøtker HE,Sørensen HT

更新日期：2015-03-07 00:00:00

abstract：BACKGROUND:A frequent disorder after stroke is neglect, resulting in a failure to report or respond to contralesional stimuli. Rehabilitation of neglect is important, given the negative influence on motor recovery, independence in self-care, transfers, and locomotion. Effects of prism adaptation (PA) to alleviate negle...

journal_title：BMC neurology

authors： Ten Brink AF,Visser-Meily JM,Nijboer TC

更新日期：2015-02-04 00:00:00

abstract：BACKGROUND:Cholinesterase inhibitors can delay the progression of Alzheimer's disease (AD). Several clinical trials of the drug in moderate to severe AD have consistently reported clinically positive effects. A combining effect with psychosocial intervention was reported in mild to moderate AD patients. Since a therape...

journal_title：BMC neurology

authors： Meguro K,Ouchi Y,Akanuma K,Meguro M,Kasai M

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Dorsolateral medullary infarction (Wallenberg syndrome) is rare in clinical practice; however, the subsequent corneal lesions are more uncommon. To our knowledge, only one such case was previously reported. We report a similar case with successful treatment and recovery, and analyse both cases to address the...

journal_title：BMC neurology

authors： Wu S,Li N,Xia F,Sidlauskas K,Lin X,Qian Y,Gao W,Zhang Q

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:The clinical impact of neutralizing antibodies against interferon-beta (NAb) is controversial. Their presence can lead to a decrease in interferon-beta (IFNβ) efficacy. Fatigue reported in patients with multiple sclerosis (MS) may be associated with an unfavorable clinical course. We conducted a prospective ...

journal_title：BMC neurology

authors： Manceau P,Latarche C,Pittion S,Edan G,de Sèze J,Massart C,Debouverie M

更新日期：2014-11-30 00:00:00

abstract：BACKGROUND:Vascular cognitive impairment-no dementia (VCIND) refers to the early or mild cognitive impairment induced by cerebral vascular injury. Research shows that serum total homocysteine (tHcy) level is an independent risk factor for cerebral vascular disease and may be closely related to cognitive function.Curren...

journal_title：BMC neurology

authors： Jiang B,Chen Y,Yao G,Yao C,Zhao H,Jia X,Zhang Y,Ge J,Qiu E,Ding C

更新日期：2014-11-30 00:00:00

abstract：BACKGROUND:Elevated intracranial pressure from cerebral edema is the major cause of early mortality in acute stroke. Current treatment strategies to limit cerebral edema are not particularly effective. Some novel anti-edema measures have shown promising early findings in experimental stroke models. Vasopressin antagoni...

journal_title：BMC neurology

authors： Hedna VS,Bidari S,Gubernick D,Ansari S,Satriotomo I,Khan AA,Qureshi AI

更新日期：2014-11-18 00:00:00

abstract：BACKGROUND:Given the increasing emphasis on the community management of spinal cord injury (SCI), strategies that could be developed and implemented in order to empower and engage individuals with SCI in promoting their health and minimizing the risk of health conditions are required. A self-management program could be...

journal_title：BMC neurology

authors： Munce SE,Fehlings MG,Straus SE,Nugaeva N,Jang E,Webster F,Jaglal SB

更新日期：2014-10-21 00:00:00

abstract：BACKGROUND:Guillain-Barré syndrome (GBS) is an autoimmune condition characterized by peripheral neuropathy. The pathogenesis of GBS is not fully understood, and the mechanism of how intravenous immunoglobulin (IVIG) cures GBS is ambiguous. Herein, we investigated lymphocyte subsets in patients with two major subtypes o...

journal_title：BMC neurology

authors： Hou HQ,Miao J,Feng XD,Han M,Song XJ,Guo L

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:Seizures are one of the most important neurologic complications of human immuno-deficiency virus (HIV)-negative cryptococcal meningitis. A better understanding of the risk associated factors can help predict those who will require treatment. METHODS:This 22-year retrospective study enrolled 180 patients. Pr...

journal_title：BMC neurology

authors： Hung CW,Chang WN,Kung CT,Tsai NW,Wang HC,Lin WC,Huang CR,Huang CC,Tsai WC,Chang HW,Su YJ,Lin YJ,Cheng BC,Chang YT,Su CM,Lu CH

更新日期：2014-10-13 00:00:00

abstract：BACKGROUND:Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospital stay post ischemic stroke on mortality is unclear. We determined whether the timing of OAC initia...

journal_title：BMC neurology

authors： Palm F,Kraus M,Safer A,Wolf J,Becher H,Grau AJ

更新日期：2014-10-08 00:00:00

abstract：BACKGROUND:Several environmental exposures, including infection with Epstein-Barr virus, low levels of vitamin D and smoking are established risk factors for multiple sclerosis (MS). Also, high hygienic standard and infection with parasites have been proposed to influence MS risk. The aim of this study was to investiga...

journal_title：BMC neurology

authors： Gustavsen MW,Page CM,Moen SM,Bjølgerud A,Berg-Hansen P,Nygaard GO,Sandvik L,Lie BA,Celius EG,Harbo HF

更新日期：2014-10-03 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage in central nervous system lymphoma is extremely rare. T2*-weighted gradient-echo magnetic resonance imaging is of particularly use in detecting silent hemorrhage as hypointense signals due to the deposition of paramagnetic hemosiderin or mineralization. Multifocal hemosiderin depositi...

journal_title：BMC neurology

authors： Yang XZ,Ni J,Cui LY

更新日期：2014-09-25 00:00:00

abstract：BACKGROUND:Dementia has been associated with an increased risk of hip fracture. However, little research has been conducted on the impact of dementia on wrist or vertebral fracture development. The aim of this study was to investigate whether dementia is a risk factor for different types of fracture in Taiwan. METHODS...

journal_title：BMC neurology

authors： Wang HK,Hung CM,Lin SH,Tai YC,Lu K,Liliang PC,Lin CW,Lee YC,Fang PH,Chang LC,Li YC

更新日期：2014-09-12 00:00:00

abstract：BACKGROUND:BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) has been recently developed as brief, practical and universal assessment tool for cognitive impairment in MS subjects. It includes the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-2 (CVLT2) and the Brief Visu...

journal_title：BMC neurology

authors： Goretti B,Niccolai C,Hakiki B,Sturchio A,Falautano M,Minacapelli E,Martinelli V,Incerti C,Nocentini U,Murgia M,Fenu G,Cocco E,Marrosu MG,Garofalo E,Ambra FI,Maddestra M,Consalvo M,Viterbo RG,Trojano M,Losignore NA,

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders that occur owing to the abnormalities in type 1 collagen, and is characterized by increased bone fragility and other extraskeletal manifestations. We report the case of a patient who was diagnosed with OI following subarachnoid hemo...

journal_title：BMC neurology

authors： Hirohata T,Miyawaki S,Mizutani A,Iwakami T,Yamada S,Nishido H,Suzuki Y,Miyamoto S,Hoya K,Murakami M,Matsuno A

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:The cognitive consequences of carbon monoxide (CO) poisoning are well described. However, most studies have been carried out without an ad-hoc group of control subjects. The main aim of this study was to evaluate cognitive and psychiatric outcome after CO exposure during the storm Klaus in the South West of ...

journal_title：BMC neurology

authors： Pages B,Planton M,Buys S,Lemesle B,Birmes P,Barbeau EJ,Maziero S,Cordier L,Cabot C,Puel M,Genestal M,Chollet F,Pariente J

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:Ventral intermediate thalamic nucleus (VIM) deep brain stimulation (DBS) is an effective treatment for tremor, but there is limited data on long-term efficacy and mortality after VIM-DBS. Here we report the analysis of patient satisfaction and mortality in all patients treated in our center 1996-2010 with VI...

journal_title：BMC neurology

authors： Børretzen MN,Bjerknes S,Sæhle T,Skjelland M,Skogseid IM,Toft M,Dietrichs E

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:Economic costs related to treatment of multiple sclerosis (MS) must be justified by health state, quality of life (QOL) and social participation improvement. This study aims to describe correlations between social participation, economic costs, utility and MS-specific QOL in a sample of patients with MS (pwM...

journal_title：BMC neurology

authors： Kwiatkowski A,Marissal JP,Pouyfaucon M,Vermersch P,Hautecoeur P,Dervaux B

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Non-ataxic symptoms of spinocerebellar ataxias (SCAs) vary widely and often overlap with various types of SCAs. Duration and severity of the disease and genetic background may play a role in such phenotypic diversity. We conducted the study in order to study clinical characteristics of common SCAs in Thailan...

journal_title：BMC neurology

authors： Boonkongchuen P,Pongpakdee S,Jindahra P,Papsing C,Peerapatmongkol P,Wetchaphanphesat S,Paiboonpol S,Dejthevaporn C,Tanprawate S,Nudsasarn A,Jariengprasert C,Muntham D,Ingsathit A,Pulkes T

更新日期：2014-04-05 00:00:00

abstract：BACKGROUND:Gait ability and cognitive function are interrelated during both normal walking (NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive impairment in both situations. However, this association is insufficiently understood in people with mild cognitive impairment (MCI). Here...

journal_title：BMC neurology

authors： Doi T,Shimada H,Makizako H,Tsutsumimoto K,Uemura K,Anan Y,Suzuki T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Women have been reported to show more frequent recanalization and better recovery after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) treatment for acute stroke compared with men. To investigate this we studied a series of stroke patients receiving IV rt-PA and undergoing acute transcrani...

journal_title：BMC neurology

authors： Al-hussain F,Hussain MS,Molina C,Uchino K,Shuaib A,Demchuk AM,Alexandrov AV,Saqqur M,CLOTBUST Investigators.

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:Cognitive disorders, such as memory disturbances, are often observed following a subarachnoid hemorrhage. We present a very rare case where rupture of a posterior cerebral artery aneurysm caused restricted damage to the hippocampus unilaterally, and caused memory disturbances. CASE PRESENTATION:A 56-year-ol...

journal_title：BMC neurology

authors： Maeshima S,Osawa A,Yamane F,Shimaguchi H,Ochiai I,Yoshihara T,Uemiya N,Kanazawa R,Ishihara S

更新日期：2014-03-07 00:00:00

abstract：BACKGROUND:Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal of exactly these frequency components from an auditory stimulus will cause the brain to reorganize ar...

journal_title：BMC neurology

authors： Pantev C,Rudack C,Stein A,Wunderlich R,Engell A,Lau P,Wollbrink A,Shaykevich A

更新日期：2014-03-02 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea is a common sleep disorder in stroke patients. Obstructive sleep apnea is associated with stroke severity and poor functional outcome. Continuous positive airway pressure seems to improve functional recovery in stroke rehabilitation. To date, the effect of continuous positive airway p...

journal_title：BMC neurology

authors： Aaronson JA,van Bennekom CA,Hofman WF,van Bezeij T,van den Aardweg JG,Groet E,Kylstra WA,Schmand BA

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:Prediction of clinical outcome in the acute stage of ischaemic stroke can be difficult when based on patient characteristics, clinical findings and on non-contrast CT. CT perfusion and CT angiography may provide additional prognostic information and guide treatment in the early stage. We present the study pr...

journal_title：BMC neurology

authors： van Seeters T,Biessels GJ,van der Schaaf IC,Dankbaar JW,Horsch AD,Luitse MJ,Niesten JM,Mali WP,Kappelle LJ,van der Graaf Y,Velthuis BK,DUST investigators.

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:Evidence indicates that the continuation of therapy among community-dwelling stroke survivors improves physical function. Community rehabilitation programmes often face limitations in terms of resources. It is imperative to include new motivational interventions to encourage some level of non-clinician manag...

journal_title：BMC neurology

authors： Singh DK,Mohd Nordin NA,Abd Aziz NA,Lim BK,Soh LC

更新日期：2013-12-13 00:00:00

abstract：BACKGROUND:Recent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinson's disease (PD). In our previous work, we sequenced the exomes of sixteen patients from eight Chinese PD families using whole exome sequencing technology, consequently three patients from different pedig...

journal_title：BMC neurology

authors： Liao XX,Zhan ZX,Luo YY,Li K,Wang JL,Guo JF,Yan XX,Xia K,Tang BS,Shen L

更新日期：2013-12-11 00:00:00